I have a 3rd party 5.25" front panel with two USB 3.0 ports. Each port goes to a single cable that connects to the USB 3.0 20-pin header on the motherboard.
Both ports usually work fine with different USB devices. But for my hard drive enclosure, it connects fine to one of the USB 3.0 ports but not the other. This is given the fact that the left port works fine with other things like USB drivers and game controllers, and that both ports have equal cable length to the motherboard header. So I really cannot think of why this would be happening. The enclosure works fine on the back USB 3.0 ports, so I assume this isn't an issue with the enclosure.
Both ports usually work fine with different USB devices. But for my hard drive enclosure, it connects fine to one of the USB 3.0 ports but not the other. This is given the fact that the left port works fine with other things like USB drivers and game controllers, and that both ports have equal cable length to the motherboard header. So I really cannot think of why this would be happening. The enclosure works fine on the back USB 3.0 ports, so I assume this isn't an issue with the enclosure.