100 disk issue no fixes yet

I've been having this issue with my computer as of recent where the disk on task manager spikes to 100% with everything at 0mb then freezes my entire computer then blue screens usually saying critical process died or kernel data inpage error when playing most games like Dark Souls 3 as an example. I've tried every answer I can find online with different power modes, removing certain programs, changing physical memory, constantly reinstalling windows and so many others. I've tried with 2 ssd's and 2 hdd's and they all have the same issue. I recently had gone away on holiday and without my permission my dad vacuumed my computer and the problems only started showing up after that happened. I'm guessing this is the cause but I have no idea what I need to do to fix it, I've been told I might need to replace my motherboard and processor but I thought I'd ask on a few different forums to check before I commit to spending a lot of money. Any help would be appreciated.